HIGHLIGHTS
SUMMARY
"naturalized" microbial populations- microbes that have evolved to primarily inhabit non-host environments (Ishii et_al, 2006; Devane et_al, 2020)-may play an important role in the origin, evolution, and dissemination of antibiotic resistance. The rapid growth of antibiotic resistance has placed an incredible burden on the health system (US Department of Health and Human Services and CDC, 2019; Serra-Burriel et_al, 2020; Nelson et_al, 2021) and without urgent action, estimates suggest that drug resistant infections will cost $100 trillion dollars (USD) and cause the deaths of 10 million people annually by 2050 (O`Neill . . .
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