Esketamine combined with pregabalin on acute postoperative pain in patients undergoing resection of spinal neoplasms: study protocol for a randomized controlled trial

HIGHLIGHTS

• who: Wanchen Sun from the This study will be a single-center, randomized, doubleblind, controlled trial with two parallel study armsThis equivalence trial aims to evaluate the analgesic effects of esketamine in combination with pregabalin after resection of spinal neoplasms. The enrolled subjects will be randomly allocated into the combined group (esketamine and pregabalin) and the control group (normal saline and placebo) in a, :, ratio. This study was approved by the Institutional Review Board of Beijing Tiantan Hospital, Capital Medical University, Beijing, China (KY-2021-08102). This study (protocol version, .4/date, .10.08) was registered on . . .
  

   

  

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