HIGHLIGHTS
SUMMARY
In human chronic kidney disease (CKD) patients, abnormalities of serum amino_acid profile have been extensively documented, with a reduction in essential_amino_acids (EAAs) and an increase in non-essential_amino_acids (NEAAs) concentrations. Serum amino_acid profile has been investigated in dogs with protein losing nephropathy, and in cats with CKD. Several abnormalities occurring during CKD, such as uremia, metabolic acidosis, and malnutrition, may contribute to disorders in serum and muscle amino_acid profiles. Beside these disorders, abnormalities in the intestinal absorption of proteins, dysbiosis, may contribute to cause derangements in serum amino_acid concentrations. For the CKD group, exceeding . . .
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