Essential function of transmembrane transcription factor myrf in promoting transcription of mirna lin-4 during c. elegans development

HIGHLIGHTS

• What: The authors demonstrate that the transmembrane transcription factor MYRF-1 is necessary for lin-4 activation. Identifying lin-4 as a potential transcriptional target of MYRF-1, the authors aimed to investigate how MYRF-1 may regulate lin-4 expression. The analysis showed that the lin-4 transcription reporter signals in the epidermis are lost in animals with the combined Cre transgene and myrf-1loxP allele, while the signals were still present in all surrounding tissues. In this experiment, the authors used the endogenously mScarlet-tagged line (umn84) to report the transcription activity of lin-4 . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.