Estimated kidney tubular secretion and kidney, cardiovascular, and mortality outcomes in ckd: the systolic blood pressure intervention trial

HIGHLIGHTS

SUMMARY

Lower estimated tubular secretion was associated with faster decline in estimated glomerular filtration rate (eGFR), independent of baseline eGFR and albuminuria, but not with CKD progression, cardiovascular disease, or mortality. The authors hypothesized that baseline estimated tubular secretion, assessed by relative urine-to-plasma concentrations of the secretion markers, would be associated with faster eGFR decline and 2 greater risk of CKD progression, CVD, and all-cause mortality, independent of baseline eGFR and albuminuria. The distribution of summary secretion scores was similar to the distribution of scores observed in the CRIC Study using similar . . .

 



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