HIGHLIGHTS
SUMMARY
Tidal volume is defined as the amount of air that moves in or out of the lungs with each respiratory cycle. Of note, the information provided by tidal volume may not be replaced by breathing rate. Indeed, tidal volume and breathing rate are differentially regulated, with the regulation of tidal volume being mainly mediated by metabolic inputs. The existence of an unbalanced interdependence between tidal volume and breathing rate has also been suggested, in which tidal volume continuously adjusts on the basis of breathing rate, but not vice versa. No study has provided an . . .
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