HIGHLIGHTS
- What: Although much has been written on the ethics of MFS trials, both in normative and empirical literature, to the knowledge no review has collected and summarized this knowledge yet, meaning that a comprehensive understanding of these issues is still lacking. According to the included literature, achieving randomization can be especially challenging in MFS trials for the following reasons. These uncertainties should be clarified within the trial, which is one of the goals of the trial itself.21,52 A trial also entails additional harms for participants. If the trial is interrupted, like the PLUTO trial, or . . .
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