HIGHLIGHTS
SUMMARY
As the incidence of malaria is decreasing in the tropics, research has focused on the proportional increase of other etiologies of acute febrile illness (AFI), including the most challenging subgroup of acute undifferentiated febrile illness, i.e., with no focal symptoms. Many single-center studies have investigated the etiologies of acute fever in various tropical areas in the past decade, and multi-country fever etiology studies are ongoing, such as FIEBRE ("Febrile Illness Evaluation in a Broad Range of Endemicities"). To the three well-established ubiquitous conditions (i.e., malaria, tuberculosis and HIV), three . . .
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