Evaluating methodological approaches to assess the severity of infection with sars-cov-2 variants: scoping review and applications on belgian covid-19 data

HIGHLIGHTS

SUMMARY

Randomization of exposure to a certain SARS-CoV-2 variant, as one would do in a randomized controlled trial (RCT), is not conceivable, making the assessment of severity of infection with variants reliant on observational data. Within the general population, severity can, among others, be approached as a visit to a general practitioner or the emergency department, hospitalization, intensive care unit (ICU) admission or death. Different vaccine types, brands and regimens, introduced at different time points, may have an impact on vaccine effectiveness. Similarly, the effectiveness of a previous infection to reduce the risk . . .

 



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