HIGHLIGHTS
- who: Christie Vermeulen and colleagues from the , HV, The Netherlands have published the research work: Evaluation of a Novel Oncolytic Adenovirus Silencing SYVN1, in the Journal: (JOURNAL)
- what: The authors show that silencing SYVN1 empowered adenovirus-mediated killing of A549 cells in_vitro and in_vivo.
- how: While the mechanism of SYVN1-mediated inhibition of adenovirus replication is not fully understood the results clearly show that RNA interference technology can be exploited to design more potent oncolytic adenoviruses.
SUMMARY
Despite very encouraging results from in_vitro and animal studies, the anticancer efficacy . . .
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