Evaluation of benzylpenicillin as an internal standard for measurement of piperacillin bone concentrations via microdialysis

HIGHLIGHTS

• who: Martin Knudsen from the Department of Clinical Medicine, Aarhus University, Denmark have published the research: Evaluation of Benzylpenicillin as an Internal Standard for Measurement of Piperacillin Bone Concentrations Via Microdialysis, in the Journal: (JOURNAL)
• what: To promote and augment clinical piperacillin pharmacokinetic studies, the authors aimed to evaluate benzylpenicillin as an internal standard for piperacillin in both in_vitro and in_vivo setups and to use the internal standard to determine porcine cancellous bone and subcutaneous tissue concentrations of piperacillin, compartments important in osteoarticular infections. An appreciable limitation to this study is that the authors only . . .
  

   

  

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