Evaluation of cell-cell interaction methods by integrating single-cell rna sequencing data with spatial information

HIGHLIGHTS

• who: Zhaoyang Liu from the Department of Orthopedics, China have published the research: Evaluation of cell-cell interaction methods by integrating single-cell RNA sequencing data with spatial information, in the Journal: (JOURNAL)
• what: The authors propose that the spatial distance suggests the interaction tendency of different cell types thus could be used for evaluating cell-cell interaction tools. The authors characterize cell-cell interactions into short-range and long-range interactions using spatial distance distributions between ligands and receptors. The statistical-based methods still have more consistent interactions with each other, which could be . . .
  

   

  

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