Evaluation of novel guanidino-containing isonipecotamide inhibitors of blood coagulation factors against sars-cov-2 virus infection

HIGHLIGHTS

• who: Flavio De Maio and collaborators from the IRCCS, Rome, Italy Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy have published the research: Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection, in the Journal: Viruses 2022, 14, 1730. of /2022/
• what: The authors evaluate in vitro the ability of approved (i.e. dabigatran and rivaroxaban) and newly synthesized isonipecotamide-based reversible inhibitors of fXa/thr (cmpds 1-3) to hinder the SARS-CoV-2 infectivity of VERO cells.
• how: All . . .
  

   

  

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