Evaluation of paclitaxel-loaded polymeric nanoparticles in 3d tumor model: impact of tumor stroma on penetration and efficacy

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• who: Dwi L. Priwitaningrum from the Faculty of and Technology, University of Twente, Drienerlolaan, AE Enschede, The Netherlands have published the article: Evaluation of paclitaxel-loaded polymeric nanoparticles in 3D tumor model: impact of tumor stroma on penetration and efficacy, in the Journal: (JOURNAL)
• what: The authors evaluated the effect of paclitaxel-loaded polymeric micelles (PTX-PMCs) and polymeric nanoparticles (PTX-PNPs) in a tumor stroma-mimicking 3D in vitro model. Altogether this study shows that the efficacy of nanotherapeutics is challenged by stroma-induced poor penetration and development of resistant phenotype. This study shows . . .
  

   

  

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