Evaluation of rhenium and technetium-99m complexes bearing quinazoline derivatives as potential egfr agents

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SUMMARY

    Synthesis of of the the Rhenium Rhenium Complexes Complexes Two new neutral hexacoordinated the Two new neutral hexacoordinated rhenium rhenium tricarbonyl tricarbonyl complexes, complexes, 5a 5a and and 7a, 7a, of of the general form fac-[Re(NNO)(CO) 3 ] and fac-[Re(SNO)(CO) 3 ] with PAMA and general form fac-[Re(NNO)(CO)3 ] and fac-[Re(SNO)(CO)3 ] with PAMA and cysteine aschelators, chelators,respectively, respectively, were synthesized. The 99m Tc complexes 5b and 7b were prepared by ligand exchange reactions using the + 2 )3 (CO)3 ] tricarbonyl complex as . . .

     

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