Evidence for chemokine-mediated coalescence of preformed flotillin hetero-oligomers in human t-cells*

HIGHLIGHTS

• who: Tommy Baumann from the Tommy Baumann, Sarah Affentranger, and Verena Niggli, From the Institute of Pathology, University of Bern, Murtenstrasse, Bern, Switzerland Background: Coexpression of the membrane microdomain-associated proteins flotillin, and , is required for their location in uropods of chemokine-stimulated, cellsResults: Coexpression of untagged flotillin, in, cells markedly enhances FRET between flotillin-1-EGFP and flotillin-1-mCherry. Conclusions: Our data strongly suggest predominant formation of flotillin hetero-oligomers in, cells. Significance: This study enhances understanding of the molecular organization of, cell uropod membrane microdomains. We have shown previously that endogenous flotillin, and, closely . . .
  

   

  

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