HIGHLIGHTS
- who: Shanta Boddapati and colleagues from the Editor:, Aarhus University, DENMARK have published the research: Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines, in the Journal: PLOS ONE of 19/07/2020
- what: The authors identified proline sequence variants substituted with hydroxyproline in recombinant antibodies produced in CHO cells and investigated the mechanism of misincorporation. Spent media analysis of the fed batch bioreactor HCCF for cell line D (growth from this experiment reported in Fig 2), confirmed that hydroxyproline is present . . .
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