Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3*

HIGHLIGHTS

• who: Thamarai K. Janganan from the cognate OMP, and it is likely that they have to reflect the dynamics of the conformational changes in the IMP, which is thought to undergo peristaltic cycling during the drug extrusion process (43, )Intriguingly the importance of the conformational flexibility during the pump function on the level of the IMP was also recently highlighted by the usage of conditional cysteine cross-linking (45, ). In summary, we demonstrate that a number of surface residues in the OMP MtrE, which are predicted to line up along the interprotomer groove, are involved in direct . . .
  

   

  

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