Evidence of somatic hypermutation in the antigen binding sites of patients with cll harboring ighv genes with 100% germline identity

HIGHLIGHTS

• who: Electra Sofou from the European Institute of Oncology (IEO), Italy University of Genoa, Italy have published the research: Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity, in the Journal: (JOURNAL)
• what: To that end, the authors focused on two well characterized major stereotyped subsets: subset #1 (clan I IGHV genes/IGHD6-19/ IGHJ4) and subset #6 (IGHV1-69/IGHD3-16/IGHJ3), displaying germline-encoded amino_acid (aa) motifs QWL and YDYVWGSY within the respective VH CDR3 that originate from the IGHD6-19 and . . .
  

   

  

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