Evidence that sprouty 2 is necessary for sarcoma formation by h-ras oncogene-transformed human fibroblasts*

HIGHLIGHTS

• who: Piro Lito from the Piro Lito, Bryan DMets, Susanne Kleff, Sandra O'Reilly, Veronica M. Maher, and J. Justin McCormick, From the Carcinogenesis Laboratory, Department of Microbiology and Molecular Genetics and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, Sprouty , (Spry2) acts as an inhibitor of receptor tyrosine kinase signaling in various cellular contexts. Interestingly, Spry, also prevents the c-Cbl-induced degradation of epidermal growth factor receptor (EGFR). We compared human fibroblasts malignantly transformed by overexpression of, Ras, oncogene to their nontransformed parental cells and found that the malignant cells express . . .
  

   

  

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