Evolution of highly pathogenic h5n1 influenza a virus in the central nervous system of ferrets

HIGHLIGHTS

• who: Jurre Y. Siegers et al. from the Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America have published the research: Evolution of highly pathogenic H5N1 influenza A virus in the central nervous system of ferrets, in the Journal: (JOURNAL) of February/16,/2023
• what: The authors evaluated the evolutionary dynamics of the virus populations entering and spreading throughout the CNS. The authors show that once inside the CNS H5N1 viruses can acquire mutations that increase the polymerase activity in vitro. The authors evaluated an H5N1 HPAI virus that acquired three substitutions . . .
  

   

  

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