Evolution of new enzymatic function by structural modulation of cysteine reactivity in pseudomonas fluorescens isocyanide hydratase[s]*

HIGHLIGHTS

• who: Mahadevan Lakshminarasimhan from the Department of Biochemistry and the Redox Biology Center, University of Nebraska, Lincoln, Nebraska, have published the article: Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase[S]*, in the Journal: (JOURNAL) of SEPTEMBER/17,/2010
• what: Asp17 has carboxylic acid are consistent with protonation and the authors propose it activates ordered molecule to hydrate organic isocyanides. The authors propose protonated carboxylic acid side chain of Asp17 donates hydrogen to cysteine thiol(ate) similar to structurally equivalent glutamic acid in human . Instead the authors . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.