HIGHLIGHTS
- who: Marina Brand from the Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, Netherlands have published the research work: Evolution of SARS-CoV-2-specific CD4, in the Journal: (JOURNAL)
- what: The authors investigated the resistance/susceptibility of T helper cell responses that are necessary for generating efficient long-lasting antibody immunity in several VOCs. The authors show that VOC spike mutations hardly affect T helper epitopes and mainly occur in other residues of the spike protein. The authors aim to study spike (u00adCD4 +) T_cell epitopes in silico and investigate the effect of vaccine selection pressure . . .
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