Evolutionary dependency of cancer mutations in gene pairs inferred by nonsynonymous-synonymous mutation ratios

HIGHLIGHTS

• What: The authors propose that dNdS ratios of gene pairs and their derived cdNS (context-dependent dNdS) scores as measure of ED distinguishing gene pairs either as synergistic (SYN) or antagonistic (ANT). The authors propose that the ED of gene pairs evaluated by dNdS ratios can advance the understanding of the functional relationship of genes with potential biological and clinical implications. wish it to be known that in their opinion the first two authors should be regarded as joint First Authors. The authors focused on well-established target agents (EGFR and BRAF inhibitors) in two tumor types . . .
  

   

  

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