HIGHLIGHTS
- who: Philippe Ortet from the CNRS Aberystwyth University have published the article: Evolutionary history expands the range of signaling interactions in hybrid multikinase networks, in the Journal: Scientific Reports Scientific Reports
- what: The experiments described in this work investigated flow of signal through the GacS-GacA TCS with domains transplanted into GacS from other TCS proteins.
- how: Using chimeras transplanting the receiver domain of GacS with receiver domains from donor hybrid HKs the authors showed that phylogenetic proximity reflects whether a transplant retains biological activity suggesting interactions were specific (although it is possible . . .
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