Evolutionary perspective of big tau structure: 4a exon variants of mapt

HIGHLIGHTS

SUMMARY

Note that these alternative splicing can generate multiple isoforms with distinct temporal and spatial distributions. system, depending on the stage of neuronal maturation and the type of neurons (Kosik et_al, 1989; Ruiz-Gabarre et_al, 2022). In most regions of the human brain, tau is present as 6 distinct isoforms that vary in the expression of exon 2, 3 at the N-terminal, and at the C-terminal exon 10, one of the microtubule-binding domains (MTBD), defining isoforms with 3 and 4 repeats (3R and 4R respectively; Andreadis, 2005; Trabzuni et_al, 2012). Tau`s . . .

 



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