Ex vivo characterization of acute myeloid leukemia patients undergoing hypomethylating agents and venetoclax regimen reveals a venetoclax-specific effect on non-suppressive regulatory t cells and bona fide pd-1+tim3+ exhausted cd8+ t cells

HIGHLIGHTS

  • What: The authors aimed to characterize the immunological repertoire of AML patients treated with VEN in combination with HMA by focusing on the modulation of IC receptors` expression. The study had new evidence in support of the ability of VEN to modulate immune cell composition and phenotype.
  • Who: Omer Jamy et al. from the University of Alabama at Birmingham, United States have published the paper: Ex vivo characterization of acute myeloid leukemia patients undergoing hypomethylating agents and venetoclax regimen reveals a venetoclax-speci c effect on non-suppressive regulatory T cells and bona de PD . . .

     

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