Ex vivo permeation parameters and skin deposition of melatonin-loaded microemulsion for treatment of alopecia

HIGHLIGHTS

• who: Asmaa A. Elshall from the MEL permeation study through rat skin was performed for the optimized ME formulae based on the guidelines implemented by Research Ethics Committee of Faculty of Pharmacy, Future University in Egypt (FUE) No (REC-FPSPI-11/78)Firstly, the rats were subjected to euthanasia through administration of sodium thiopental overdose, and then, abdominal hair removal took place through shaving using an electric shaver. After removing all abdominal hair, full-thickness rat skin was removed and examined for any bites, scratches or anomalies prior carefully removing the subcutaneous fat without causing any damage . . .
  

   

  

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