Exacerbation of cisplatin cellular toxicity by regulation of the human organic cation transporter 2 through angiotensin ii

HIGHLIGHTS

  • who: Marta Kantauskaite and colleagues from the Experimental Nephrology, Department of Internal Medicine D, University Hospital Mu00fcnster, Mu00fcnster, Germany have published the Article: Exacerbation of Cisplatin Cellular Toxicity by Regulation of the Human Organic Cation Transporter 2 through Angiotensin II, in the Journal: (JOURNAL)
  • what: In this work the regulation of hOCT2 activity by AII and its role in the development of CDDP cellular toxicity was investigated. The authors showed that AII can stimulate the hOCT2 activity when the transporter is expressed in cells, which polarize and form distinguished apical and basolateral membrane domains. Using . . .

     

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