Excess ribosomal protein production unbalances translation in a model of fragile x syndrome

HIGHLIGHTS

• who: Sang S. Seo from the University of have published the article: Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Recent studies using ribosome profiling and RNA-seq have provided important support for this model, showing that there is a reduction in ribosome pausing along long mRNAs in Fmr1-/y brain13,14. This analysis shows a significant overlap between the upregulated populations and identified 92 candidates (Supplementary Fig 2e and Supplementary Data 6). This study provides multiple novel insights into the nature . . .
  

   

  

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