Excessive immunosuppression by regulatory t cells antagonizes t cell response to schistosome infection in pd-1-deficient mice

HIGHLIGHTS

• who: Liaoxun Lu and colleagues from the Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Medical, Affiliated Hospital of Medical, China, Centre d`Immunologie de MarseilleLuminy, Aix Marseille Universitu00e9, Marseille, France have published the paper: Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice, in the Journal: (JOURNAL)
• what: PD-1 deficiency significantly increases T_cell numbers in the liver during chronic infection of S. japonicum Since S. japonicum infection induces high levels of PD-1 expression in CD4+ and CD8+ T_cells and impairs T_cell proliferation . . .
  

   

  

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