HIGHLIGHTS
SUMMARY
There is, however, a large variability in the effectiveness of exercise-based lifestyle interventions regarding therapeutic 2 of 7 targets, such as improvement of blood glucose control or reduction of adipose_tissue mass, that cannot satisfactorily be explained up to now. Lac-Phe has been proposed to be a novel "exerkine" that lowers body weight and adipose_tissue mass in obese mice. This prompted the authors to assess whether differences in the reduction in adipose_tissue volume during an exercise intervention could be related to differences in the exercise-induced production of Lac-Phe in humans, where . . .
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