HIGHLIGHTS
SUMMARY
Overnutrition and the excessive accumulation of white adipose_tissue (WAT) affect systemic inflammatory status and disrupt gluco-metabolic homeostasis by altering the functionality of central and peripheral tissues, including the hypothalamus. Recent evidence suggests that the positive effects exerted by exercise on systemic metabolic health can be in part mediated by the hypothalamus. This review discusses animal and human evidence to highlight the positive effect of regular exercise on obesity-induced hypothalamic inflammation/dysfunction. High fat diet (HFD)-fed mice display an upregulation of the main pro-inflammatory pathways-c-Jun N-terminal kinase (JNK . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.