Exogenous administration of low-dose lipopolysaccharide potentiates liver fibrosis in a choline-deficient l-amino-acid-defined diet-induced murine steatohepatitis model

HIGHLIGHTS

  • who: Keisuke Nakanishi and collaborators from the Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan have published the paper: Exogenous Administration of Low-Dose Lipopolysaccharide Potentiates Liver Fibrosis in a Choline-Deficient l-Amino-Acid-Defined Diet-Induced Murine Steatohepatitis Model, in the Journal: (JOURNAL)
  • what: Although this model provides mechanistic evidence of the interaction between increased LPS and NASH progression, it is not completely suitable as a human NASH-mimicking model, as it exhibits remarkable weight loss and lacks IR. The authors aimed to (i) clarify the impact of LPS challenge . . .

     

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