Exome-wide association study to identify rare variants influencing covid-19 outcomes: results from the host genetics initiative

HIGHLIGHTS

SUMMARY

Unless large sample sizes and careful statistical adjustments are used, most rare variant genetic associations studies risk being underpowered, and are at higher risk of false or inflated effect estimates if significant associations are found between COVID-19 and genetic loci. The authors investigated the association of rare genetic variants on the risk of COVID-19 by combining gene burden test results from whole exome and whole genome sequencing. The authors build off recent work on exome-wide analyses and include close to 5 times the number of severe cases, with a more genetically . . .

 



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