Exoribonuclease and endoribonuclease activities of rnase bn/rnase z both function in vivo*

HIGHLIGHTS

• who: Tanmay Dutta from the Tanmay Dutta, Arun Malhotra, and Murray PDeutscher, From the Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida , Background: In contrast to other RNase Z endoribonucleases, RNase BN is also an exoribonuclease in vitro. Results: Cells dependent on RNase BN for growth are affected by a single amino acid change that eliminates exoribonuclease activity. Conclusions: In addition to its endoribonuclease activity, the exoribonuclease of RNase BN also can participate in tRNA maturation. Significance: RNase BN can serve as a dual function nuclease in vivo. Escherichia coli . . .
  

   

  

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