HIGHLIGHTS
- who: Sarah M. Roelle and collaborators from the Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United have published the paper: Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains, in the Journal: (JOURNAL) of July/27,/2022
- what: The authors characterize the extent of ACE2 dependence across sarbecovirus clades. The study provides a new genetic approach for characterizing receptor utilization during viral entry and demonstrated that clade 3 sarbecoviruses likely utilize ACE2 as a cellentry receptor during infection. The authors focused on further developing a flexible pseudovirus infection . . .
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