Expanding the diversity at the c-4 position of pyrido[2,3-d]pyrimidin-7(8h)-ones to achieve biological activity against zap-70

HIGHLIGHTS

• who: Victor Masip and collaborators from the Department of Hematology, Hospital Universitari Vall d'Hebron, Experimental Hematology, Vall d'Hebron have published the article: Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70, in the Journal: Pharmaceuticals 2021, 14, 1311. of /2021/
• what: In this paper a general synthetic methodology for the synthesis of 4-substituted-2-(phenylamino)-5 6-dihydropyrid pyrimidin-7(8H)-ones is described.
• how: The authors employed a triflate group not only to carry . . .
  

   

  

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