Expanding the malaria antibody toolkit: development and characterisation of plasmodium falciparum rh5, cyrpa, and csp recombinant human monoclonal antibodies

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  • who: Adu00e9la Nacer from the Deakin University, Australia have published the Article: Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies, in the Journal: (JOURNAL)
  • how: To ensure the authors captured sequence diversity for these highly polymorphic antigens the authors used sequence information available from MalariaGEN (MalariaGen et_al 2021). Cell culture supernatants from the 33 PfRH5 antibody clones were tested for antigen binding using biolayer interferometry (BLI) which identified 18 PfRH5 mAbs with blocking activity. All the antibodies described were tested individually. The microarray data . . .

     

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