HIGHLIGHTS
SUMMARY
Dalbavancin is a lipoglycopeptide antibiotic whose mechanism of action involves the disruption of cell wall synthesis by binding to the D-alanyl-D-alanine end of the peptidoglycan structure in the forming cell wall, preventing cross-linking (transpeptidation and transglycosylation) of disaccharide subunits, resulting in bacterial cell death. Dalbavancin is usually used off-label, as it has a powerful activity against Grampositive pathogens that cause bone and joint infections (osteomyelitis), bacteraemias and endocarditis, among others, which are infections that require long-term antibiotic therapy and long periods of hospitalization. Its prolonged action allows for . . .
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