HIGHLIGHTS
SUMMARY
In normal mice without any immune or stem_cell deficiency, competitive pressure from the host prevented donor cell engraftment and the level of chimerism remained very low (Carrier et_al, 1995; Kim et_al, 1998; Donahue et_al, 2001). Previous studies have shown that clonal deletion, anergy, and induction of donor-specific Tregs are essential for the induction of immune tolerance (Kim et_al, 1999; Hayashi et_al, 2004; Merianos et_al, 2009; Nijagal et_al, 2011a; Nijagal et_al, 2011b). The sheep model also demonstrated persistent xenogeneic engraftment after transplantation of human HSCs (Zanjani et_al, 1992b; Srour et_al, 1992; Srour et_al, 1993 . . .
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