Experimental and theoretical studies on the anti-amyloidogenic and destabilizing effects of pyrogallol against human insulin protein

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  • who: Pyrogallol et al. from the Lorestan University Faculty of Basic Science have published the Article: Experimental and Theoretical Studies on the Anti-Amyloidogenic and Destabilizing Effects of Pyrogallol Against Human Insulin Protein, in the Journal: (JOURNAL)
  • what: The sigmoid curve obtained in this study showed that HI fibrillation follows the nucleation-dependent elongation mechanism (Nielsen et_al 2001). The results of molecular docking simulation in this study showed that Py was able to interact with HI through hydrophobic_interactions and hydrogen_bonding, thereby resulting in the inhibition of HI fibrillation. The results of this study demonstrated that . . .

     

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