Experimental and theoretical studies on the synthesis of 1,4,5-trisubstituted pyrrolidine-2,3-diones

HIGHLIGHTS

  • who: Nguyen Tran Nguyen and colleagues from the Department of, University of Science and Education, the have published the article: Experimental and theoretical studies on the synthesis of 1,4,5-trisubstituted pyrrolidine-2,3-diones, in the Journal: (JOURNAL)
  • what: The authors report the synthesis of 4-acetyl-3-hydroxy-3-pyrroline-2-ones via multicomponent reactions of ethyl 2,4-dioxovalerate with aromatic aldehydes, and aniline in glacial acetic acid.
  • how: In this work DFT calculations were used to investigate the synthesis of 145-trisubstituted pyrrolidine-23-dione (10ab) from 2 . . .

     

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