Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays

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  • who: Clifford G. Phaneuf from the Barnett InstituteNortheastern University Disease Profiling and Functional Genomics, Cambridge, MA, Thermo Fisher Scientific, Bremen, Germany. , Tarmeta Biosciences, Natick, MA, USA. have published the Article: Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays, in the Journal: (JOURNAL) of 25/07/2022
  • what: The authors developed an MS-TSA model system for the assessment of small molecule-protein interactions using intact cells treated with a commercially available highly specific mitogen-activated protein kinase (MEK) 1-2 inhibitor to prepare a set of unfractionated test samples . . .

     

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