Exploitation of cd3ζ to enhance tcr expression levels and antigen-specific t cell function

HIGHLIGHTS

• What: The authors showed that the level of TCR expression on the surface of human T_cells is regulated by the CD3 chains.
• Who: Michelle Krogsgaard et al. from the New York University, United States have published the paper: Exploitation of CD3 to enhance TCR expression levels and antigen-speci c T cell function, in the Journal: (JOURNAL)
• How: The authors used the HEK293T (Human Embryonic Kidney) cells that lack endogenous CD3 and TCR. The data indicated that the z chain is the key regulator of TCR surface levels since provision of additional edg . . .
  

   

  

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