Exploiting enzyme evolution for computational protein design

HIGHLIGHTS

• who: Gaspar P. Pinto from the DepartmentUppsala University have published the research: Exploiting enzyme evolution for computational protein design, in the Journal: (JOURNAL)
• what: In this review the authors discuss three directions where evolutionary information is being used to guide the computational design process specifically: (i) repurposing of scaffolds identified through as potential starting points for the generation of new enzyme activities; (ii) harnessing conformational dynamics key driver of natural enzyme evolution in computational enzyme design; and_(iii) modular design processes based on identifying evolutionarily important subdomain segments that can be rearranged to create new . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.