Exploring the active site of the streptococcus pneumoniae topoisomerase iv-dna cleavage complex with novel 7,8-bridged fluoroquinolones

HIGHLIGHTS

• who: X-ray crystallography et al. from the London , UL, UK Molecular and Clinical Sciences Research Institute, St George’s, University of London, Cranmer Terrace have published the paper: Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones, in the Journal: (JOURNAL) of 31/08/2022
• what: The authors report the structures of the topoisomerase IV-DNA cleavage complexes with ACHN-245 and ACHN-454 at 3.43 and 3.24 Å resolution, respectively.

SUMMARY

Quinolone agents, which target type II . . .

 



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