Exploring the causal association between genetically determined circulating metabolome and hemorrhagic stroke

HIGHLIGHTS

• What: The authors evaluated the causal relationship between human blood metabolites and the risk of hemorrhagic stroke using a two-sample bidirectional MR design. The authors show the specific features of the above datasets in Supplementary Table S2. Bidirectional two-sample MR analyses, combined with robustness checks of the results, after correction for p-values, Pyroglutamylglycine (Peptide), biliverdin (Cofactors and vitamins), linoleate (18:2n6) (Lipid), eicosenoate (20:1n9 or 11) (Lipid), gammaglutamylmethionine*(Peptide), For this study, the authors selected to explore the causal associations between 309 known CSMs and HS by using eight different large GWAS datasets . . .
  

   

  

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