Exploring the impact of irradiation on glioblastoma blood-brain-barrier permeability: insights from dynamic-contrast-enhanced-mri and histological analysis

HIGHLIGHTS

• What: This study explores whether irradiation can enhance BBB permeability by assessing hemodynamic changes and the distribution of contrast agents in the core and the margins of GB tumors. The series of methods that have been used in this study are similar to those used in a companion paper where the authors investigated the effect of a hyperosmolar shock on the integrity of the BBB by both histology and DCE-MRI. The authors focused on assessing the ability of irradiation to improve the delivery of compounds into the tumor margins. This model has the advantage of high . . .
  

   

  

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