Exploring the neuroprotective effects of rufinamide in a streptozotocin-induced dementia model

HIGHLIGHTS

• What: This study aimed to determine the involvement of the CREB pathway in the cognitive improvement effects of rufinamide in STZ (streptozotocin) induced mouse model of dementia. In the current study, the effects of rufinamide (50 and 100 mg/kg i.p.) in STZ-induced dementia on various behavioral and biochemical parameters were explored. In the current study, therefore, the AChE enzyme activity was evaluated. In the present study, memory was examined using stepdown passive avoidance and Morris water maze tests.
• Who: Darshpreet Kaur from the Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India . . .
  

   

  

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